Neurotransmitters are chemicals that transmit signals between neurons, playing pivotal roles in sleep. GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter that promotes sleep by reducing neuronal activity. Serotonin, found in the raphe nuclei, regulates sleep stages and mood. Orexin (also known as hypocretin) is crucial for maintaining wakefulness, and its deficiency is linked to narcolepsy.