Yes, restless legs syndrome (RLS), characterized by an uncontrollable urge to move the legs, especially at night, has been linked to specific genetic variants. Polymorphisms in the MEIS1, BTBD9, and MAP2K5/SKOR1 genes have been associated with an increased risk of developing RLS. These genes are involved in iron metabolism, dopamine production, and other pathways critical for normal neurological function.
