What Conditions are Associated with Hypocretin Deficiency?
The most well-known condition associated with hypocretin deficiency is narcolepsy type 1. This sleep disorder is characterized by excessive daytime sleepiness, cataplexy (sudden muscle weakness), sleep paralysis, and hallucinations. Individuals with narcolepsy type 1 often have very low or undetectable levels of hypocretin in their cerebrospinal fluid.
