For patients who cannot tolerate CPAP, alternative treatments include oral appliances, positional therapy, and surgical options. Oral appliances can help reposition the jaw and tongue to keep the airway open. Positional therapy involves strategies to avoid sleeping on the back, where apneas are more likely to occur. Surgical options, such as uvulopalatopharyngoplasty (UPPP) or hypoglossal nerve stimulation, may be considered for severe cases or those unresponsive to other treatments.